Peptide to Reduce Fat and Increase Glucose Sensitivity

It has been shown that leptin exerts its action partly by activation of the melanocortin system in the brain. Melanotan 2 (MT-2) signals the melanocortin system and plays an important role in fat loss, glucose tolerance and insulin sensitivity.

But is it true? Indeed it is.

It has been shown that leptin exerts its action partly by activation of the melanocortin system in the brain. Melanotan 2 (MT-2) signals the melanocortin system and plays an important role in fat loss, glucose tolerance and insulin sensitivity. Melanocortins can bypass leptin, induce an appetite suppressant and preform miracles.

Nutrient partitioning is an aspect of fat loss from Melanotan 2 which has been established. Diets higher in fat are better associated with the use of agonists (MT-2). There is a great effort to develop agonists (Melanotan 2) and antagonists of peptide receptors that have been associated specifically with energy and fat loss. Dosing and timing are particularly complicated areas of study as melanocortin systems vary so greatly. The melanocortin system represents an attractive target (MC4R) for leptin related obesity research.

I have found and experienced meal size and meal choice being effected after melanocortin manipulation. Melanocortin receptor 4 (MC4R) affects food intake and energy expenditure. Feeding behavior affected by MC4R signaling are being unraveled in clinical study today. Maybe more interesting, the application of MCR agonists (Melanotan 2) have side effects such as erections/aphrodisiac sensation. This may complicate introduction of these proteins in the treatment of obesity, lol.

A natural agonist, a-MSH (Melanotan 2) reduces food intake suggesting the MC4R might become useful in obesity treatment. MC3R has been suggested to play a role in nutrient partitioning. Development of MC4R and MC3R agonists have been addressed in order to reduce weight dramatically.